Job Description

Job Title: Research Scientist II, DMPK

Annual Base Salary: DOE, $128,000-$175,000 along with bonus eligibility and a comprehensive benefits package

Location: Los Angeles, CA

Our Mission

The Ellison Medical Institute, formerly known as the Ellison Institute of Technology Los Angeles, strives to spark innovation, leverage technology, and drive interdisciplinary, patient-centered research to continually enhance health, reimagine and redefine cancer care, and transform lives.

Established in 2016 as a medical research and development center, the Institute features innovation labs for artificial intelligence and molecular analytics and was among the first organizations to vertically integrate the interdisciplinary study and treatment of disease. We offer multifaceted programs, including a preventative medicine and cancer clinic, cross-disciplinary research laboratories, a health policy think-tank, and community outreach and educational programs.

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Job Summary

The Ellison Medical Institute is seeking an accomplished and passionate Research Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to join our Translational Biology team. In this high-impact role, you will apply your expertise in pharmacokinetics (PK), toxicology (TOX), and drug metabolism (ADME) to accelerate the advancement of groundbreaking new molecular entities. Your work will directly contribute to optimizing drug properties and ensuring that our innovative drug candidates are ready for clinical trials.

As a subject matter expert, you’ll design and lead PK/TOX studies, working closely with both internal teams and Contract Research Organizations (CROs) to ensure rigorous compliance with regulatory standards and IND-enabling requirements. Collaborating with early-stage and preclinical development teams, you'll drive innovative approaches, incorporating new technologies and methodologies to expand our drug discovery pipeline.

This is a unique opportunity to be at the forefront of early-stage drug development, in a collaborative, multidisciplinary environment, where your contributions will help shape the future of medicine.

Why You Should Join Us:

• Drive Innovation: Contribute to the advancement of cutting-edge drug development and therapeutic strategies that transform patient care.
• Be at the Forefront: Work with a world-class team and integrate new technologies in PK/TOX and ADME studies to accelerate the drug discovery pipeline.
• Make an Impact: Help shape clinical trial strategies and regulatory pathways that will support the successful progression of therapeutic candidates into clinical trials.

Job Accountabilities:

• Lead PK/TOX and ADME Studies : Design and manage PK, TOX, and ADME studies to optimize drug properties and prepare for regulatory submission. Oversee study execution both internally and through CROs.
• Data Analysis and Modeling : Analyze and interpret PK/TOX and ADME data using industry-standard tools, including human PK predictions and clinical translation, to inform drug development decisions.
• CRO Management and Oversight : Build strong relationships with external CROs, ensuring study quality, compliance with regulatory standards, and alignment with IND-enabling requirements.
• Cross-Functional Collaboration : Collaborate closely with clinical, engineering, and biochemistry teams to provide guidance on PK/TOX strategies and data interpretation, enhancing overall drug discovery efforts.
• Innovation and Technology Integration : Work with early and preclinical development teams to integrate cutting-edge technologies and methodologies, driving the innovation of PK and toxicology assessments to expand the drug discovery pipeline.

ADDITIONAL INFORMATION

Required Education & Experience:

• PhD in Pharmacokinetics, Toxicology, Drug Metabolism, Pharmaceutical Sciences, Pharmacology, or a related field, with 2+ years of relevant industry experience ; or MS in the same fields with 5+ years of industry experience in DMPK, pharmacology, or toxicology.
• Proven track record of designing and interpreting PK/TOX and ADME studies to support drug discovery and development.
• Expertise in analyzing and modeling PK, TOX, and ADME data, including human PK predictions and clinical translation, using industry-standard software tools.
• Experience managing CROs conducting PK/TOX studies, ensuring quality, compliance, and alignment with IND-enabling requirements.
• Experience working across multiple drug modalities, including small molecules and biologics, is preferred.

For the safety and health of employees, guests, and patients, the Ellison Medical Institute may mandate vaccination requirements for employment. The Ellison Medical Institute's policies are always subject to review and change to ensure they are appropriate under the circumstances.

The Ellison Medical Institute is an equal opportunity employer. We believe that an inclusive, collaborative team environment is just as important to our mission as stethoscopes and microscopes. We strive to always provide employees a supportive atmosphere, so they feel confident taking creative risks toward innovation. The Ellison Medical Institute values emotional intelligence and communication with empathy and respect for others. We seek to build a diverse group of people who are curious, have a deep sense of responsibility, and the grit needed to achieve excellence.

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